Light & Engineering 33 (1) 2025

Volume 33
Date of publication 02/20/2025
Pages 56–60

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Pupillary Response changes to Flickering Light Stimuli in Human L&E, Vol.33, No.1, 2025

Articles authors:

Ryuma Semba, Yu Maruyama, Hajime Nakajima, Masanori Kuroha, Shota Matsukawa, Genta Tsuchihashi, Motoharu Takao

Ryuma Semba, a Master’s student, majoring in information science at Tokai University, Japan. He is conducting a study on circadian photoentrainment in humans under the supervision of Prof. Motoharu Takao

Yu Maruyama, a Master’s student, majoring in information science at Tokai University, Japan. He is researching the effects of chromatic light on circadian rhythm in humans alongside Ryuma Semba. He is a member of Prof. Takao’s laboratory

Hajime Nakajima is an undergraduate student majoring in information science at Tokai University, Japan. He is a member of a research team studying light entrainment of the human circadian rhythm under the guidance of Prof. Motoharu Takao

Masanori Kuroha is an undergraduate student majoring in information science at Tokai University. He is a part of a team studying the relationship between pupil response and lighting under the direction of Prof. Motoharu Takao

Shota Matsukawa is an undergraduate student majoring in information science at Tokai University. He is conducting research on information processing involving human subjects in a laboratory supervised by Prof. Motoharu Takao

Genta Tsuchihashi is an undergraduate student majoring in information science at Tokai University. He is currently conducting research on pupil responses to flickering light. He is affiliated with Prof. Motoharu Takao

Motoharu Takao, Ph. D., Professor. He obtained his Ph. D. from Osaka University, Japan. He received academic training at Brown University, USA, and the National Institute for Basic Biology, Japan. His primary interest lies in the neural mechanisms of circadian photoentrainment, but he also explores a wide range of academic fields related to human cognitive activities

Abstract:

The circadian rhythm is related to cells called intrinsic photosensitive retinal ganglion cells (ipRGC) which are strongly influenced by light. Pupillary responses during light stimulation are attributed to photoreceptors, while pupillary responses after light exposure are attributed to ipRGCs. This study explores the characteristics of pupillary response to flickering light stimuli, indicating diurnal changes in chromatic sensitivity of ipRGCs by measuring the pupillary light reflex after exposure to flickering light. The results showed that, overall, no relationship was found between the time of day and wavelength. There was no significant difference between the three time zones of 10:00, 13:00, and 16:00. However, there were significant differences in wavelength comparisons during and after light exposure. The results indicate that pupillary light response to the middle wavelength (517 nm) was larger than to short and long wavelength (454 nm and 627 nm), therefore indicating that green cone photoreceptors are involved in flickering light, while light response after short wavelength light exposure took longest time to recover.

References:

1. Kozaki, T., & Okuzono, M. Attempting to evaluate non-visual effect of the light by steady-state electroretinogram // The Japanese Journal of Ergonomics, 2021, 57 (Supplement).
2. Berson, D.M., Dunn, F.A., Takao, M. Phototransduction by retinal ganglion cells that set the circadian clock // Science, 2002, 295 (5557), pp. 1073–1077.
3. Gamlin, P.D., McDougal, D.H., Pokorny, J., Smith, V.C., Yau, K.W., Dacey, D.M. Human and macaque pupil responses driven by melanopsin-containing retinal ganglion cells // Vision Research, 2007, 47(7), pp. 946–54.
4. Adhikari, P., Feigl, B., & Zele, A.J. The flicker pupil light response (FPLR) // Translational Vision Science & Technology, 2019, 8(5), 29.
5. Kaneyoshi, I., Akio, M., et al. The results of investigation by the Japanese version of Morningness-Eveningness Questionnaire // The Japanese Journal of Psychology, 01 Jun 1986, 57 (2), pp. 87–91, Language: jpn, https://doi.org/10.4992/jjpsy.57.87.
6. Tetso, K., & Lee S. Recent studies on the contribution intrinsically photosensitive retinal ganglion cells to visual functions // The Japanese Journal of Ergonomics, 2021, 26 (4), pp. 87–95.
7. Akpınar, S., Tek, N.A. Age-Related Changes in Circadian Rhythm and Association with Nutrition // Current nutrition reports, 2023, 12 (3), pp. 376–382.

Keywords

DOI: https://doi.org/10.33383/2024-059

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